Endocrine Abstracts

Introduction: In humans, Cushing’s syndrome (CS) is associated with an increased incidence of the metabolic syndrome, increased cardiovascular morbidity and mortality, even after long-term correction of glucocorticoid (GC) excess.Aim: To evaluate the effects of transient overexposure to GC on the metabolic changes in the long-term in mice.Methods: Single housed male C57Bl/6J mice were given corticosterone (CORT; 50 μg/ml)...

Introduction: Persistent hyperparathyroidism is reported to occur in 0–6% of cases after initial surgery for sporadic primary hyperparathyroidism (PHPT). The management of these cases is complex, however, with a poor cure rate despite repeated surgery. The aim of our study was to identify the challenges and pitfalls encountered in the management of a series of patients with persistent hyperparathyroidism after initial parathyroidectomy.Patients and ...

Background: Leiden University Medical Center, Leiden, The Netherlands; 2Leiden University Medical Center, Leiden, The Netherlands; 3Leiden University Medical Center, Leiden, The NetherlandsBackground: Arthropathy is an invalidating complication of acromegaly, despite persisting biochemical disease control, which has a high impact on the quality of life (QoL). The prognosis and determinants are currently unknown.<p class="abstext...